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Medetomidine Withdrawal Explained: A New Toxidrome and the MOWS Protocol

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Real stories. Bold science. Conversations that transform addiction care.

The Azar Lab Podcast blends science and storytelling, featuring patients, families, and experts who share transformative insights about addiction and recovery.

 

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Medetomidine Withdrawal Explained: A New Toxidrome and the MOWS Protocol

All episodes

SIFI Protocol Explained: Symptom Inhibited Fentanyl Induction for Refractory Opioid Withdrawal

SIFI Protocol Explained: Symptom Inhibited Fentanyl Induction for Refractory Opioid Withdrawal

5m

The SIFI protocol was developed in response to the extreme opioid tolerance seen in the fentanyl era.

Medetomidine Withdrawal Explained: A New Toxidrome and the MOWS Protocol

Medetomidine Withdrawal Explained: A New Toxidrome and the MOWS Protocol

5m

A frontline explainer on medetomidine withdrawal and the new MOWS protocol—designed to recognize alpha-2 agonist toxidromes early and prevent ICU escalation.

Medetomidine & Xylazine: Alpha-2 Agonists Reshaping the Overdose Crisis

Medetomidine & Xylazine: Alpha-2 Agonists Reshaping the Overdose Crisis

40m

Alpha-2 agonists like xylazine and medetomidine are rapidly changing the illicit drug supply — and creating a new, more severe dependence and withdrawal syndrome that clinicians are now confronting across the U.S. East Coast and increasingly in British Columbia.

In this episode, Dr. Pouya Azar speaks with Dr. Jeanmarie Perrone, Professor of Emergency Medicine at the University of Pennsylvania and a leading expert in medical toxicology and addiction medicine, about how these non-opioid sedatives entered the fentanyl supply, why they are so potent, and what their emergence means for overdose risk, withdrawal management, and frontline care.

Brandon Turner on Skateboarding, Trauma & Recovery

Brandon Turner on Skateboarding, Trauma & Recovery

1h 58m

Professional skateboarder Brandon Turner shares a raw account of his journey through childhood trauma, addiction, incarceration, and recovery. From turning pro to surviving prison and near-death experiences, Brandon reflects on the moments that forced real change—and how he’s now giving back as the founder of Westside Recovery in San Diego.

Addiction, withdrawal, mental health and homelessness with Justin Acheson

Addiction, withdrawal, mental health and homelessness with Justin Acheson

37m

In this powerful interview, Justin Acheson shares his lived experience navigating addiction, recovery, and the complex systems that shape both. With candor and clarity, Justin reflects on what it means to heal in a world that often misunderstands the roots of substance use—and the real pathways to care.

Gordon Faulkner: Breaking Free From Anxiety

Gordon Faulkner: Breaking Free From Anxiety

1h 35m

Gordon shares how hypnosis helped him manage anxiety and become more authentic.

Ben Degros: Skateboarding, Recovery & the Road Forward

Ben Degros: Skateboarding, Recovery & the Road Forward

1h 41m

A journey from skateboarding to addiction recovery and healing.

Peter Gooderham: Brain Surgeon Talks About Pursuing Excellence

Peter Gooderham: Brain Surgeon Talks About Pursuing Excellence

1h 29m

Insights into the grind and mindset behind becoming a brain surgeon.

Conor King & Korey Bedard: The Fentanyl Crisis

Conor King & Korey Bedard: The Fentanyl Crisis

1h 33m

A timely discussion on the fentanyl crisis with two experts.

Patient Shares His Recovery Journey

Patient Shares His Recovery Journey

1h 9m

A personal testimonial from a patient in recovery.

Losing a Beloved Son/Brother to the Fentanyl Crisis

Losing a Beloved Son/Brother to the Fentanyl Crisis

1h 16m

Anne and daughter share their experience losing a son to fentanyl and the impact on their family.

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