Medetomidine Withdrawal Explained: A New Toxidrome and the MOWS Protocol
Medetomidine Withdrawal Explained: A New Toxidrome and the MOWS Protocol
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Medetomidine & Xylazine: Alpha-2 Agonists Reshaping the Overdose Crisis
40m
Alpha-2 agonists like xylazine and medetomidine are rapidly changing the illicit drug supply — and creating a new, more severe dependence and withdrawal syndrome that clinicians are now confronting across the U.S. East Coast and increasingly in British Columbia.
In this episode, Dr. Pouya Azar speaks with Dr. Jeanmarie Perrone, Professor of Emergency Medicine at the University of Pennsylvania and a leading expert in medical toxicology and addiction medicine, about how these non-opioid sedatives entered the fentanyl supply, why they are so potent, and what their emergence means for overdose risk, withdrawal management, and frontline care.
Brandon Turner on Skateboarding, Trauma & Recovery
1h 58m
Professional skateboarder Brandon Turner shares a raw account of his journey through childhood trauma, addiction, incarceration, and recovery. From turning pro to surviving prison and near-death experiences, Brandon reflects on the moments that forced real change—and how he’s now giving back as the founder of Westside Recovery in San Diego.
Addiction, withdrawal, mental health and homelessness with Justin Acheson
37m
In this powerful interview, Justin Acheson shares his lived experience navigating addiction, recovery, and the complex systems that shape both. With candor and clarity, Justin reflects on what it means to heal in a world that often misunderstands the roots of substance use—and the real pathways to care.







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